GastroPlus download

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GastroPlus is a computer program for Windows 95/98/NT/2000 & XP platforms that simulates absorption and pharmacokinetics for orally dosed drugs. The underlying model is the Advanced Compartmental Absorption and Transit (ACAT) model - an extension of work originally done by Gordon Amidon and Lawrence Yu.

GastroPlus includes:

• Physiological models for human (fasted and fed), beagle dog (fasted and fed), rat, mouse, rabbit and cat
• Peff converter to convert user-measured permeability to human in vivo Peff
• pH-dependent solubility and logD models
• Dissolution dependence on particle size and particle density
• One-, two-, or three-compartment pharmacokinetics
• Controlled release dosage forms including gastric retention, dispersed release and integral tablet
• Automatic model fitting and formulation design (with optional Optimization Module)
• Saturable gut & liver metabolism and gut transport (with optional Metabolism and Transporter Module)
• Ability to simultaneously fit pharmacokinetic parameters to IV and oral data
• In Vitro - In Vivo Correlation (with optional IVIV Correlation Module)

Download GastroPlus